Dynamic Optical Networks for Data Centres and Media Production

This thesis explores all-optical networks for data centres, with a particular focus on network designs for live media production. A design for an all-optical data centre network is presented, with experimental verification of the feasibility of the network data plane. The design uses fast tunable (< 200 ns) lasers and coherent receivers across a passive optical star coupler core, forming a network capable of reaching over 1000 nodes. Experimental transmission of 25 Gb/s data across the network core, with combined wavelength switching and time division multiplexing (WS-TDM), is demonstrated. Enhancements to laser tuning time via current pre-emphasis are discussed, including experimental demonstration of fast wavelength switching (< 35 ns) of a single laser between all combinations of 96 wavelengths spaced at 50 GHz over a range wider than the optical C-band. Methods of increasing the overall network throughput by using a higher complexity modulation format are also described, along with designs for line codes to enable pulse amplitude modulation across the WS-TDM network core. The construction of an optical star coupler network core is investigated, by evaluating methods of constructing large star couplers from smaller optical coupler components. By using optical circuit switches to rearrange star coupler connectivity, the network can be partitioned, creating independent reserves of bandwidth and resulting in increased overall network throughput. Several topologies for constructing a star from optical couplers are compared, and algorithms for optimum construction methods are presented. All of the designs target strict criteria for the flexible and dynamic creation of multicast groups, which will enable future live media production workflows in data centres. The data throughput performance of the network designs is simulated under synthetic and practical media production traffic scenarios, showing improved throughput when reconfigurable star couplers are used compared to a single large star. An energy consumption evaluation shows reduced network power consumption compared to incumbent and other proposed data centre network technologies

Beyond outputs: pathways to symmetrical evaluations of university sustainable development partnerships

As the United Nations Decade of Education for Sustainable Development (2005–2014) draws to a close, it is timely to review ways in which the sustainable development initiatives of higher education institutions have been, and can be, evaluated. In their efforts to document and assess collaborative sustainable development program outcomes and impacts, universities in the North and South are challenged by similar conundrums that confront development agencies. This article explores pathways to symmetrical evaluations of transnationally partnered research, curricula, and public-outreach initiatives specifically devoted to sustainable development. Drawing on extensive literature and informed by international development experience, the authors present a novel framework for evaluating transnational higher education partnerships devoted to sustainable development that addresses design, management, capacity building, and institutional outreach. The framework is applied by assessing several full-term African higher education evaluation case studies with a view toward identifying key limitations and suggesting useful future symmetrical evaluation pathways. University participants in transnational sustainable development initiatives, and their supporting donors, would be well-served by utilizing an inclusive evaluation framework that is infused with principles of symmetry

Perspectives on ENCODE

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.11Nsciescopu

Expanded encyclopaedias of DNA elements in the human and mouse genomes

AbstractThe human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE1 and Roadmap Epigenomics2 data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.11Nsciescopu